Fool me once, shame on you. Fool me twice...
After the loss of Mary Winchester, the hunters gather to say their goodbyes but the time for grieving is short. With Jack still out there, Bobby refuses to sit around and plans on doing everything he can to track the Nephilim down. In his determination to save him, Castiel reaches out to heaven and meets with Duma.
A shell, incapable of holding life.
After arriving back at the bunker, Sam and Dean expected to see Jack and Mary but find themselves alone. When Dean calls Mary, him and Sam hear her phone in the room and know that something is wrong. They call Jack but he doesn't answer. They track his phone only to find him hopping across the planet from one continent to the next.
No turning back.
While getting ready for game night at the bunker, Dean has an alarming voicemail from Donatello – begging for help before speaking a mysterious language. Dean and Mary rush to his home only to find Nick waiting for them. He has Donatello and injected him with a lethal dose of poison. If they want to find him they have to give him what he wants.
If you hear a whistle, run.
After a girl is found dead in the woods in Iowa from a strange animal attack, Sam digs deeper and has found that several people have been found dead the in the same area across the past few decades. It's a case and one that will get him and Dean out of the bunker.
WWWD. What would the Winchesters do?
Still reeling from the loss of Maggie and the other hunters, Sam is running the tea ragged going from one hunt to the next. After he finds a new case where a man's head exploded inside of a gas station, Dean puts his foot down and insists that they need to slow down.
It's all about Dean.
While tracking the strange killings of several people, the latest case has the Winchesters in New Mexico where they are once again too late to stop the monster. The gang notices that both of the victim's eyes have been removed – something that leaves all of them puzzles.
The walking dead.
Sam and Dean's latest case brings them into a music shop but the Winchesters are interested in some of the finer goods. After flashing some cash at the clerk, he takes them into the back to show them his rare occult relics that are for sale, except the boys know that he stole them from the hunter that he killed to get them.
The Impala confessional.
Dean Winchester has a plan. To save the world, he plans on locking himself in a coffin and being dropped into the ocean. Sam is unwilling to let his brother go through this alone and while they prepare, he is intent on doing everything he can to stop his brother from going through with it.
Some people are broken. Others can't be saved.
Now that Michael is trapped within Dean's mind, Sam's worry for his brother is at an all time high. Even so, Dean needs some time to reset and plans to visit Mary at the cabin – alone. On his way, he stops and sees Donna but even the Sheriff notices that Dean seems off.
In the battle for control of Dean's body, Michael will use his most devastating angel ability yet – guilt.
Michael may have pulled a fast one on the Winchesters but it was Sam and Castiel that came prepared with special angels cuffs that would neutralize the powers of an archangel.