Hey, teachers! Leave them kids alone.
After a teacher is found dead with his tongue ripped out and his organs crushed, the Winchesters have their latest case in Des Moines, Iowa. They ask Mary if she's up for taking a case with them but she's been busy killing demons with Mr. Ketch of the British Men of Letters.
When Dean gets hit with a magic spell that erases memory, Sam has to save his brother before there is nothing left.
After waking up in a forest with no idea how he got there, Dean manages to call Sam and have him meet him for waffles at the nearby diner. It's there that he sees a girl that he has no recollection of from last night and promptly gets a slap in the face.
Dean, she is married to Jesus.
Following a recent string of suicides from members of a congregation in Massachusetts, the Winchesters have a case. Using their latest FBI disguises, they talk with Father Delaney and Sister Mathias for any help they can get. Elsewhere, in hell, Crowley isn't lacking for complaints about his mother.